Potentiation of norepinephrine and adenosine in the renal circulation by 2,6-bis (diethanolamino)-4,8-dipiperidino-pyrimido (5,4-d) pyrimidine (dipyridamole) treatment (preliminary report).

APO-DIPYRIDAMOLE/ASPIRIN CAPSULES NAME OF THE MEDICINE Dipyridamole Chemical Name: 2,6-bis(diethanolamino)-4,8-dipiperidino-pyrimido[5,4-d]pyrimidine Structural Formula: Molecular Formula: C24H40N8O4 Molecular Weight: 504.6 CAS Registry Number: 58-32-2 Aspirin Chemical Name: 2-acetoxybenzoic acid Structural Formula: Molecular Formula: C9H8O4 Molecular Weight: 180.2 CAS Registry Number: 50-78-2

Influence of a Pyrimidopyrimidine Derivative on Deamination of Adenosine by Blood.

• A new synthetic compound, Persantin (RA-8 or 2,6-Bis(diethanolamino)-4,8-dipiperidino-pyTimido(5,4-d) -pyrimidine), has recently been reported to produce coronary vasodilation without an associated increase in cardiac work. Although the mechanism responsible for the coronary vasodilation produced by Persantin has not been elucidated, there are some indications that an indirect action on myoca...

Influence of a Pyrlmidopyrimidine Derivative on Deamination of Adenosine by Blood

• A new synthetic compound, Persantin (RA-8 or 2,6-Bis(diethanolamino)-4,8-dipiperidino-pyTimido(5,4-d) -pyrimidine), has recently been reported to produce coronary vasodilation without an associated increase in cardiac work. Although the mechanism responsible for the coronary vasodilation produced by Persantin has not been elucidated, there are some indications that an indirect action on myoca...

Dipyridamole inhibits hydroxylamine augmented nitric oxide (NO) production by activated polymorphonuclear neutrophils through an adenosine-independent mechanism.

Polymorphonuclear neutrophils (PMN) are thought to play a role in reperfusion injury and ischemia. These effects are partly mediated by toxic oxygen species (superoxide anion, hydrogen peroxide and hydroxyl radical) acting at the level of the endothelium. It was demonstrated recently that the superoxide anion reacts with nitric oxide (NO) and that interaction leads to the generation of highly t...

Developmental aspects of hepatic and extrahepatic drug-metabolizing enzyme systems: microsomal enzymes and components in rabbit liver and lung during the first month of life.

AND BRENDA COLASANTI 23 Acetylcholinesterase Inhibition and Morphine Effects in Morphine Tolerant and Dependent Mice. HEMENDRA N. BHARGAVA AND E. LEONG WAY 31 Studies on the Transport of Morphine into the Cerebrospinal Fluid of Rabbits. J. H. WANG AND A. E. TAKEMORI 41 The Effect of 6-Hydroxydopamine on Morphine Tolerance and Physical Dependence. GLADYS FRIEDLER, HEMENDRA H. BHARGAVA, RAYMOND Q...